|MOPML062||Accelerator Neutron Source for Boron Neutron Capture Therapy||neutron, vacuum, proton, experiment||550|
Funding: This study was carried out with a grant from the Russian Science Foundation (project No. 14-32-00006-P) with the support of the Budker Institute of Nuclear Physics and Novosibirsk State University.
A source of epithermal neutrons based on a vacuum-insulated tandem accelerator and a lithium target is developed for the technique of boron neutron capture therapy. A stationary proton beam of 2 MeV with a current of up to 5 mA was obtained in the accelerator. Neutron generation was performed and the flux and neutron spectrum were experimentally measured. A Beam Shaping Assembly was developed and manufactured, which makes it possible to form a therapeutic beam of neutrons to the greatest extent satisfying the requirements of BNCT. It was established that neutron irradiation of tumor cells of human glioma U251 and human glioblastoma T98G, previously incubated in a medium with boron, led to a significant suppression of their viability. Irradiation of mice with grafted human glioblastoma tumor led to their complete cure. In order to increase the beam parameters, the facility was equipped with a wire scanner OWS-30 (D-Pace, Canada; under the license of TRIUMF), a non-contact current sensor NPTC (Bergos, France), a FLIR T650SC infrared camera, an Optris CT Laser 3ML SF pyrometer (Optris, GmbH, Germany), cooled diaphragms with thermistors, telescopic beam receivers with thermoresistors, a new bushing insulator. Two new sources of negative hydrogen ions with a high current are being prepared, one of them is surface-plasma, the other is voluminous. The investigations established the effect of space charge and spherical aberration of lens on the ion beam transport, the dependence of the heating of the diaphragms of the electrodes and the size of the proton beam on the current of the injected beam of negative hydrogen ions and the pressure of the residual gas in the transport channel. The report describes the modernization of the accelerator, discusses the results of research, declares plans.
|DOI •||reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2018-MOPML062|
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